MyBioSource.com's KLKB1 Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The KLKB1 Antibody (C-term) was generated using kallikrein B1, KALP15, KLKB1, and Miscellaneous as the antigen and it reacts with Human.
Description
Plasma prekallikrein is a glycoprotein that participates
in the surface-dependent activation of blood coagulation,
fibrinolysis, kinin generation and inflammation. It is synthesized
in the liver and secreted into the blood as a single polypeptide
chain. Plasma prekallikrein is converted to plasma kallikrein by
factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma
kallikrein therefore is composed of a heavy chain and a light chain
held together by a disulphide bond. The heavy chain originates
from the amino-terminal end of the zymogen and contains 4 tandem
repeats of 90 or 91 amino acids. Each repeat harbors a novel
structure called the apple domain. The heavy chain is required for
the surface-dependent pro-coagulant activity of plasma kallikrein.
The light chain contains the active site or catalytic domain of the
enzyme and is homologous to the trypsin family of serine proteases.
Plasma prekallikrein deficiency causes a prolonged activated
partial thromboplastin time in patients